Publication of IMPRS-LS student Lorenzo Galanti
Galanti, L., and Pfander, B.
EMBO J, 2018, [Epub ahead of print].
Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase
The DNA replication checkpoint (DRC) and the DNA damage checkpoint (DDC) are two closely linked signaling cascades that adjust S phase to the presence of DNA lesions and other replication impediments. Two recent studies published in The EMBO Journal shed new light on their relationship in budding yeast, collectively showing that the two pathways—while sharing several factors—differ in the location and kinetics of their activation, suggesting that they constitute different branches of an integrated cellular response to impaired DNA replication.