Research Group Leader - Émilie Macé

Brain-Wide Circuits for Behavioral Control



CV:

Emilie Mace

starting 2019: Group leader at the Max Planck Institute of Neurobiology, Munich, Germany
2015 – 2019 : Postdoctoral Fellow, Roska Laboratory, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2012 – 2015: Postdoctoral Fellow, Vision Institute, Paris, France
2008 – 2011 : PhD in Physics, Langevin Institute, Paris, France
2007 – 2008 : Master in Bioimaging Sciences, Imperial College, London, UK
2004 –2007 : Engineering degree, Ecole Superieure de Physique et Chimie Industrielles, Paris, France


Research Projects:

How distributed brain networks cooperate to produce behavior is a fundamental question in neuroscience. Advances in neurotechnology, primarily applied to mice, have revealed insights into the neuronal computations that underlie behavior at the microcircuit level. However, these circuit studies mostly focus on only one or two candidate brain regions at a time: a whole-brain view is missing due to a lack of methods to record whole-brain activity during mouse behavior. I previously developed functional ultrasound imaging, a method for recording whole-brain activity in behaving mice at high spatial resolution (100 µm). The goal of my lab is to extend this approach to study how mice switch between behaviors in a natural environment, and identify the whole-brain networks underlying these switches. In a natural context, the brain deals with a large number of possible actions and must continuously integrate both internal states and external stimuli when selecting the next behavior. How this basic function is implemented in the whole-brain remains elusive, but functional ultrasound imaging combined with the circuit tools available in mice offer an opportunity to address it. Moreover, my lab investigates how the whole-brain networks involved in behavioral switching are altered in psychiatric disorders, focusing on depression, in which there is impairment of the initiation of innate behaviors, and obsessive-compulsive disorders which lead to excessive engagement in specific behaviors.


List of Publications: (underlined are the 2 most relevant publications)

2018
E. Macé, G. Montaldo, S. Trenholm, C. Cowan, A. Brignall, A. Urban and B. Roska, “Brain modules for visuomotor integration revealed by whole-brain functional ultrasound imaging”. Neuron, vol. 100, pp. 1241–1251.e7, Dec 2018.

2017
S. Deny, U. Ferrari, E. Macé, P. Yger, R. Caplette, S. Picaud, G. Tkacik and O. Marre, “Multiplexed computations in retinal ganglion cells of a single type.”  Nature Communications, vol. 8, no 1, pp 1964, Dec 2017.
 
A. Chaffiol*, R. Caplette*, C. Jaillard*, E. Brazhnikova, M. Desrosiers, E. Dubus, L. Duhamel, E. Macé, O. Marre, P. Benoit, P. Hantraye, A.-P. Bemelmans, E. Bamberg, J. Duebel, J.-A. Sahel, S. Picaud and D. Dalkara, “New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.”  Molecular Therapy, vol. 25, no 11, pp. 2546-2560. Nov 2017.

2016
A.Sengupta*, A. Chaffiol*, E. Macé, R. Caplette, M. Desrosiers, M. Lampič, V. Forster, O. Marre, J. Y Lin, J.- A. Sahel, S. Picaud, D. Dalkara and J. Duebel, “Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.”  EMBO Molecular Medicine, vol. 8, no. 11, pp. 1248-1264, Nov 2016.

2015
E. Macé*, R. Caplette*, O. Marre*, A. Sengupta, A. Chaffiol, P. Barbe, M. Desrosiers, B. Roska, J.-A. Sahel, S. Picaud, J. Duebel and D. Dalkara, “Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV restores visual responses in blind mice.”  Molecular Therapy, vol. 23, no. 1, pp. 7-16, Jan 2015.

A.Urban*, C. Dussaux*, G. Martel, C. Brunel, E. Macé, G. Montaldo, “Real-time imaging of brain activity in freely moving rats using functional ultrasound.”  Nature Methods, vol. 12, no. 9, pp. 873-878, Sep 2015.

2014
A. Urban*, E. Macé*, C. Brunner, M. Heidmann, J. Rossier and G. Montaldo, “Chronic assessment of cerebral hemodynamics during rat forepaw electrical stimulation using functional ultrasound imaging.” Neuroimage, vol. 101, pp. 138-149, Nov 2014.

2013
E. Macé, G. Montaldo, B. Osmanski, I. Cohen, M. Fink and M. Tanter, “Functional ultrasound imaging of the brain: theory and basic principles.” IEEE Transactions on Ultrasonic, Ferroelectrics and Frequency Control,  vol. 60, no. 3, pp. 492–506, Mar 2013.

2012
A. Martin, E. Macé, R. Boisgard, G. Montaldo, B. Thézé, M. Tanter and B. Tavitian, “Imaging of perfusion, angiogenesis and tissue elasticity after stroke”. Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 8, pp. 1496 - 1507, Aug 2012.

2011
E. Macé, G. Montaldo, I. Cohen, M. Baulac, M. Fink and M. Tanter, “Functional ultrasound imaging of the brain.”  Nature  Methods, vol. 8, no. 8, pp. 662-664, Aug 2011.

E. Macé, I. Cohen, G. Montaldo, R. Miles, M. Fink and M. Tanter, “In vivo mapping of brain elasticity in small animals using shear wave imaging.” IEEE Transactions on Medical Imaging, vol. 30, no. 3, pp. 550–558, Mar 2011.

2010
J.-L. Gennisson, T. Deffieux, E. Macé, G. Montaldo, M. Fink and M. Tanter, “Viscoelastic and anisotropic mechanical properties of in vivo muscle tissue assessed by supersonic shear imaging.” Ultrasound in Medicine and Biology, vol. 36, no. 5, pp. 789–801, May 2010.

2009
D. Mohammad-Aghaie, E. Macé, C. A. Sennoga, J. M. Seddon and F. Bresme, “Molecular dynamics simulations of liquid condensed to liquid expanded transitions in dppc monolayers.” Journal of Physical Chemistry B, vol. 114, no. 3, pp. 1325–1335, Jan 2010.

(*equal contribution)