Publication of IMPRS-LS student Stefan Bauernfried

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Bauernfried, S., and Hornung, V.
Nat Struct Mol Biol, 2021, 28, 333-336.
doi: 10.1038/s41594-021-00580-y

DPP9 restrains NLRP1 activation

NLRP1 was the first inflammasome-forming sensor to be identified, but only recently has its mode of action been in the spotlight. Two groups now report cryo-EM structures demonstrating how NLRP1 is kept in check by the dipeptidyl peptidase DPP9, and they illuminate how DPP9 inhibition leads to NLRP1 inflammasome activation.