Publication of IMPRS-LS student Stefan Bauernfried
Bauernfried, S., and Hornung, V.
Nat Struct Mol Biol, 2021, 28, 333-336.
DPP9 restrains NLRP1 activation
NLRP1 was the first inflammasome-forming sensor to be identified, but only recently has its mode of action been in the spotlight. Two groups now report cryo-EM structures demonstrating how NLRP1 is kept in check by the dipeptidyl peptidase DPP9, and they illuminate how DPP9 inhibition leads to NLRP1 inflammasome activation.