Publication of IMPRS-LS student Kheewoong Baek
Baek, K., and Schulman, B.A.
Nat Chem Biol, 2019, [Epub ahead of print].
Molecular glue concept solidifies
Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.