Publication of IMPRS-LS student Charlotte Blessing
Blessing, C., and Ladurner, A.G.
Nat Struct Mol Biol, [Epub ahead of print].
Tickling PARPs into serine action
Poly-(ADP-ribosylation) is a post-translational modification with broad roles in cell signaling. A recently reported crystal structure reveals how the accessory factor HPF1 extends the catalytic active site of PARP1 and PARP2 to promote the specific ADP-ribosylation of serine residues, a prerequisite for dynamic chromatin changes induced by DNA damage.